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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of intestine from wild type and Mdm2 knock-out mice

ABSTRACT: Analyzed gene expression in 3-day old mice lacking Mdm2 in the intestine

ORGANISM(S): Mus musculus

SUBMITTER: Yasmine Valentin-Vega

PROVIDER: E-MEXP-1431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.

Valentin-Vega Y A YA Okano H H Lozano G G

Cell death and differentiation 20080718 11

Mdm2 is the major inhibitor of the p53 tumor suppressor. Loss of Mdm2 in mice or in specific tissues of the mouse always yields p53-dependent lethal phenotypes. However, the role of Mdm2 in tissues with high turnover capacity is unknown. We have engineered mice lacking Mdm2 in the intestinal epithelium using the Cre/LoxP system. Loss of Mdm2 (Mdm2(intDelta)) results in viable animals, but neonates display multiple intestinal abnormalities such as hyperplasia, enterocyte vacuolization, and inflam ...[more]

PMID: 18636077

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