Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nobuyuki Yamasaki
PROVIDER: E-MEXP-962 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yamasaki Nobuyuki N Maekawa Motoko M Kobayashi Katsunori K Kajii Yasushi Y Maeda Jun J Soma Miho M Takao Keizo K Tanda Koichi K Ohira Koji K Toyama Keiko K Kanzaki Kouji K Fukunaga Kohji K Sudo Yusuke Y Ichinose Hiroshi H Ikeda Masashi M Iwata Nakao N Ozaki Norio N Suzuki Hidenori H Higuchi Makoto M Suhara Tetsuya T Yuasa Shigeki S Miyakawa Tsuyoshi T
Molecular brain 20080910
Elucidating the neural and genetic factors underlying psychiatric illness is hampered by current methods of clinical diagnosis. The identification and investigation of clinical endophenotypes may be one solution, but represents a considerable challenge in human subjects. Here we report that mice heterozygous for a null mutation of the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha-CaMKII+/-) have profoundly dysregulated behaviours and impaired neuronal development in the ...[more]