Transcription profiling of human chronic lymphocytic leukemia samples and pRS-15/16 transfected MEG01 cell lines to identify MiR-15a and miR-16-1 cluster function in human leukemia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Massimo Negrini
PROVIDER: E-MEXP-1482 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MiR-15a and miR-16-1 cluster functions in human leukemia.
Calin George A GA Cimmino Amelia A Fabbri Muller M Ferracin Manuela M Wojcik Sylwia E SE Shimizu Masayoshi M Taccioli Cristian C Zanesi Nicola N Garzon Ramiro R Aqeilan Rami I RI Alder Hansjuerg H Volinia Stefano S Rassenti Laura L Liu Xiuping X Liu Chang-Gong CG Kipps Thomas J TJ Negrini Massimo M Croce Carlo M CM
Proceedings of the National Academy of Sciences of the United States of America 20080324 13
MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles in human diseases, including cancer. Each miRNA is predicted to regulate hundreds of transcripts, but only few have experimental validation. In chronic lymphocytic leukemia (CLL), the most common adult human leukemia, miR-15a and miR-16-1 are lost or down-regulated in the majority of cases. After our previous work indicating a tumor suppressor function of miR-15a/16-1 by targeting the BCL2 oncogene, here, we p ...[more]
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