Unknown,Transcriptomics,Genomics,Proteomics

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Chromatin immunopreciptiation of human breast epithelial HME1 cell lines over-expressing wild type or mutant p53 to study acetylation of histone H3


ABSTRACT: acetylation of histone H3 was studied using ChIP on chip technique in breast epithelial HME1 cell lines overexpressing wt or mutant p53

ORGANISM(S): Homo sapiens

SUBMITTER: Lukas Vrba 

PROVIDER: E-MEXP-1493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

p53 induces distinct epigenetic states at its direct target promoters.

Vrba Lukas L   Junk Damian J DJ   Novak Petr P   Futscher Bernard W BW  

BMC genomics 20081015


<h4>Background</h4>The tumor suppressor protein p53 is a transcription factor that is mutated in many cancers. Regulation of gene expression by binding of wild-type p53 to its target sites is accompanied by changes in epigenetic marks like histone acetylation. We studied DNA binding and epigenetic changes induced by wild-type and mutant p53 in non-malignant hTERT-immortalized human mammary epithelial cells overexpressing either wild-type p53 or one of four p53 mutants (R175H, R249S, R273H and R2  ...[more]

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