Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Paul Badenhorst
PROVIDER: E-MEXP-1513 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kwon So Yeon SY Xiao Hua H Glover Bradley P BP Tjian Robert R Wu Carl C Badenhorst Paul P
Developmental biology 20080212 2
The Drosophila nucleosome remodeling factor (NURF) is an ISWI-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. By sliding nucleosomes, NURF has the ability to alter chromatin structure and regulate transcription. Previous studies have shown that mutation of Drosophila NURF induces melanotic tumors, implicating NURF in innate immune function. Here, we show that NURF mutants exhibit identical innate immune responses to gain-of-function mutants in the Drosoph ...[more]