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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Bordetella bronchiseptica virulent swine isolate KM22, wild type and fhaB and prn deletion mutants

ABSTRACT: B. bronchiseptica strain KM22, a virulent swine isolate, and strains TN27 and TN28, fhaB and prn deletion mutants of KM22, respectively, were cultured in Stainer-Scholte broth and grown at 37C with shaking at 275 rpm until an OD600 of 0.8 was reached. RNA extracted from KM22 was then compared to RNA extracted from TN27 and TN28.

ORGANISM(S): Bordetella bronchiseptica

SUBMITTER: Tracy Nicholson

PROVIDER: E-MEXP-1558 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Contribution of Bordetella bronchiseptica filamentous hemagglutinin and pertactin to respiratory disease in swine.

Nicholson Tracy L TL Brockmeier Susan L SL Loving Crystal L CL

Infection and immunity 20090223 5

Bordetella bronchiseptica is pervasive in swine populations and plays multiple roles in respiratory disease. Most studies addressing virulence factors of B. bronchiseptica are based on isolates derived from hosts other than pigs. Two well-studied virulence factors implicated in the adhesion process are filamentous hemagglutinin (FHA) and pertactin (PRN). We hypothesized that both FHA and PRN would serve critical roles in the adhesion process and be necessary for colonization of the swine respira ...[more]

PMID: 19237531

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