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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat differentiated RN46A cells after acute paroxetine exposure

ABSTRACT: Effect of acute paroxetine exposure on differentiated RN46A cells

ORGANISM(S): Rattus norvegicus

SUBMITTER: Dylan Glubb

PROVIDER: E-MEXP-1582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine.

Glubb D M DM McHugh P C PC Deng X X Joyce P R PR Kennedy M A MA

The pharmacogenomics journal 20090728 2

To identify genes that may be relevant to the molecular action of antidepressants, we investigated transcriptional changes induced by the selective serotonin reuptake inhibitor paroxetine in a serotonergic cell line. We examined gene expression changes after acute treatment with paroxetine and sought to validate microarray results by quantitative PCR (qPCR). Concordant transcriptional changes were confirmed for 14 genes by qPCR and five of these, including the adrenomedullin gene (Adm), either a ...[more]

PMID: 19636336

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