RNA-seq of Pluripotent Stem Cell-Derived Endometrial Stromal Fibroblasts in Monolayer Differentiation and in Co-culture with Endometrial Epithelial Organoids
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Noboru Sakabe
PROVIDER: E-MTAB-10375 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua.
Cheung Virginia Chu VC Peng Chian-Yu CY Marinić Mirna M Sakabe Noboru J NJ Aneas Ivy I Lynch Vincent J VJ Ober Carole C Nobrega Marcelo A MA Kessler John A JA
Cell reports 20210501 7
Various human diseases and pregnancy-related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as spontaneous decidualization, and no existing human cell cultures recapitulate the cyclic interactions between endometrial stromal and epithelial compartments necessary for decidualization and implantation. Here we report a protocol differentiating human pluripotent stem cells into endometrial stromal fibro ...[more]
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