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Transcription profiling of mouse lymphomagenesis induced by conditional expression of transgenic c-Myc oncogene in six different tumor cell lines

ABSTRACT: Lymphomagenesis was induced by conditional expression of transgenic c-Myc oncogene. Profile of genes expressed in tumor cells was compared with profile of genes in the same cell line treated for 12 hours with doxycycline to abrogate expression of transgenic c-Myc. Six different tumor cell lines were tested.

ORGANISM(S): Mus musculus

SUBMITTER: Dragan Marinkovic

PROVIDER: E-MEXP-169 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of novel Myc target genes with a potential role in lymphomagenesis.

Marinkovic Dragan D Marinkovic Tatjana T Kokai Eniko E Barth Thomas T Möller Peter P Wirth Thomas T

Nucleic acids research 20041011 18

The c-Myc transcription factor regulates a wide set of genes involved in processes such as proliferation, differentiation and apoptosis. Therefore, altered expression of Myc leads to deregulation of a large number of target genes and, as a consequence, to tumorigenesis. For understanding Myc-induced transformation, identification of these target genes is essential. In this study, we searched for Myc target genes involved in lymphomagenesis using different mouse T and B cell lymphoma cell lines t ...[more]

PMID: 15477387

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