Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse hematopoietic Baf-3 cells inducibly expressing transcription factor Sp1


ABSTRACT: Inducible expression of transcription factor Sp1 in hematopoietic baf-3 cells

ORGANISM(S): Mus musculus

SUBMITTER: Yann LEVERRIER 

PROVIDER: E-MEXP-1702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>The ubiquitous transcription factor Sp1 regulates the expression of a vast number of genes involved in many cellular functions ranging from differentiation to proliferation and apoptosis. Sp1 expression levels show a dramatic increase during transformation and this could play a critical role for tumour development or maintenance. Although Sp1 deregulation might be beneficial for tumour cells, its overexpression induces apoptosis of untransformed cells. Here we further characte  ...[more]

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