Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of liver from wild type and RXR-alpha deficient matured and aged mcie

ABSTRACT: Compare the gene expression profiles from the 6 and 24 month old WT with RXRa specific hepatic deficiency mice in both genders

ORGANISM(S): Mus musculus

SUBMITTER: Minglei Guo

PROVIDER: E-MEXP-1711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner.

Guo Minglei M Gong Lei L He Lin L Lehman-McKeeman Lois L Wan Yu-Jui Yvonne YJ

BMC genomics 20080828

<h4>Background</h4>The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid x receptor alpha (RXRalpha) are involved in hepatocellular carcinogenesis. The phenotype of hepatocyte RXRalpha deficient mice is different between genders. To explore the impact of hepatocyte RXRalpha deficiency on gender-dependent hepatic gene expression, we compared the expression profiles of cancer-related genes in 6 and 24 m ...[more]

PMID: 18755030

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Dataset Information

Transcription profiling of liver from wild type and RXR-alpha deficient matured and aged mcie

Publications

Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner.

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