Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNAi knock down of Imd, Basket and Relish in Drosophila cells treated with LPS and luciferase


ABSTRACT: Imd, Basket and Relish (the Drosophila JNK and NF-kB homolog, respectively) genes were knock-downed individually by RNAi, and we compared the gene expression patterns in response to LPS with those of control samples treated with luciferase RNAi.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Young-Hwa Song 

PROVIDER: E-MEXP-177 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules.

Kim Taeil T   Yoon Joonsun J   Cho Hwansung H   Lee Wook-Bin WB   Kim Joon J   Song Young-Hwa YH   Kim Se Nyun SN   Yoon Jeong Ho JH   Kim-Ha Jeongsil J   Kim Young-Joon YJ  

Nature immunology 20050109 2


IkappaB kinase (IKK) and Jun N-terminal kinase (Jnk) signaling modules are important in the synthesis of immune effector molecules during innate immune responses against lipopolysaccharide and peptidoglycan. However, the regulatory mechanisms required for specificity and termination of these immune responses are unclear. We show here that crosstalk occurred between the drosophila Jnk and IKK pathways, which led to downregulation of each other's activity. The inhibitory action of Jnk was mediated  ...[more]

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