Unknown,Transcriptomics,Genomics,Proteomics

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Comparative genomic hybridization of human hepatoblastomas identifies two tumor subclasses resembling distinct phases of liver development

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/C/B?B=-catenin signaling. Microarray analysis identifitwo tumor subclasses resembling distinct phases of liver development typified by gains of chromosomes 8q and 2p and upregulated Myc signaling.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Marie-Annick Buendia 

PROVIDER: E-MEXP-1852 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.

Cairo Stefano S   Armengol Carolina C   De Reyniès Aurélien A   Wei Yu Y   Thomas Emilie E   Renard Claire-Angélique CA   Goga Andrei A   Balakrishnan Asha A   Semeraro Michaela M   Gresh Lionel L   Pontoglio Marco M   Strick-Marchand Hélène H   Levillayer Florence F   Nouet Yann Y   Rickman David D   Gauthier Frédéric F   Branchereau Sophie S   Brugières Laurence L   Laithier Véronique V   Bouvier Raymonde R   Boman Françoise F   Basso Giuseppe G   Michiels Jean-François JF   Hofman Paul P   Arbez-Gindre Francine F   Jouan Hélène H   Rousselet-Chapeau Marie-Christine MC   Berrebi Dominique D   Marcellin Luc L   Plenat François F   Zachar Dominique D   Joubert Madeleine M   Selves Janick J   Pasquier Dominique D   Bioulac-Sage Paulette P   Grotzer Michael M   Childs Margaret M   Fabre Monique M   Buendia Marie-Annick MA  

Cancer cell 20081201 6

Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chrom  ...[more]

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