Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of human well-differentiated leiomyosarcomas and undifferentiated sarcomas


ABSTRACT: Experiment compares transcription profiles of well-differentiated leiomyosarcomas, and undifferentiated sarcomas

ORGANISM(S): Homo sapiens

DISEASE(S): undifferentiated sarcoma

SUBMITTER: Alain AURIAS 

PROVIDER: E-MEXP-1922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.

Pérot Gaëlle G   Derré Josette J   Coindre Jean-Michel JM   Tirode Franck F   Lucchesi Carlo C   Mariani Odette O   Gibault Laure L   Guillou Louis L   Terrier Philippe P   Aurias Alain A  

Cancer research 20090310 6


Myocardin (MYOCD), a serum response factor (SRF) transcriptional cofactor, is essential for cardiac and smooth muscle development and differentiation. We show here by array-based comparative genomic hybridization, fluorescence in situ hybridization, and expression analysis approaches that MYOCD gene is highly amplified and overexpressed in human retroperitoneal leiomyosarcomas (LMS), a very aggressive well-differentiated tumor. MYOCD inactivation by shRNA in a human LMS cell line with MYOCD locu  ...[more]

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