Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human HepG2 cells treated with TCDD


ABSTRACT: The integration of different M-^SomicsM-^T technologies has already been shown in several in vivo studies to offer a complementary insight into cellular responses of toxic processes. We therefore hypothesize that the combining of transcriptomics and metabonomics data may improve the understanding of molecular mechanisms underlying non-genotoxic carcinogenicity in vitro. To test this hypothesis, the human hepatocarcinoma cell line HepG2 was exposed to the well known environmental pollutant TCDD.

A custom CDF file is available on the FTP site for this experiment (in file E-MEXP-2817.additional.zip) for use with the normalized data file for this experiment.

ORGANISM(S): Homo sapiens

SUBMITTER: Danyel Jennen 

PROVIDER: E-MEXP-2817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells.

Jennen Danyel D   Ruiz-Aracama Ainhoa A   Magkoufopoulou Christina C   Peijnenburg Ad A   Lommen Arjen A   van Delft Joost J   Kleinjans Jos J  

BMC systems biology 20110831


<h4>Background</h4>The integration of different 'omics' technologies has already been shown in several in vivo studies to offer a complementary insight into cellular responses to toxic challenges. Being interested in developing in vitro cellular models as alternative to animal-based toxicity assays, we hypothesize that combining transcriptomics and metabonomics data improves the understanding of molecular mechanisms underlying the effects caused by a toxic compound also in vitro in human cells.  ...[more]

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