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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of fission yeast as telomeres shorten in trt1- strains, and to compare survivors with linear and circular chromosomes

ABSTRACT: Time course experiment to watch RNA expression profiles as telomeres shorten in trt1- strains, and to compare survivors with linear and circular chromosomes.

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Jeffrey Mandell

PROVIDER: E-MEXP-201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global expression changes resulting from loss of telomeric DNA in fission yeast.

Mandell Jeffrey G JG Bähler Jürg J Volpe Thomas A TA Martienssen Robert A RA Cech Thomas R TR

Genome biology 20041215 1

<h4>Background</h4>Schizosaccharomyces pombe cells lacking the catalytic subunit of telomerase (encoded by trt1+) lose telomeric DNA and enter crisis, but rare survivors arise with either circular or linear chromosomes. Survivors with linear chromosomes have normal growth rates and morphology, but those with circular chromosomes have growth defects and are enlarged. We report the global gene-expression response of S. pombe to loss of trt1+.<h4>Results</h4>Survivors with linear chromosomes had ex ...[more]

PMID: 15642092

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