Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Jeffrey Mandell
PROVIDER: E-MEXP-201 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mandell Jeffrey G JG Bähler Jürg J Volpe Thomas A TA Martienssen Robert A RA Cech Thomas R TR
Genome biology 20041215 1
<h4>Background</h4>Schizosaccharomyces pombe cells lacking the catalytic subunit of telomerase (encoded by trt1+) lose telomeric DNA and enter crisis, but rare survivors arise with either circular or linear chromosomes. Survivors with linear chromosomes have normal growth rates and morphology, but those with circular chromosomes have growth defects and are enlarged. We report the global gene-expression response of S. pombe to loss of trt1+.<h4>Results</h4>Survivors with linear chromosomes had ex ...[more]