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Transcription profiling of fission yeast wild type and zinc regulatory null mutant grown in low zinc growth conditions

ABSTRACT: Transcription profile of low zinc growth condition in zinc regulatory null mutant

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Stephen Watt

PROVIDER: E-TABM-427 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Response of Schizosaccharomyces pombe to zinc deficiency.

Dainty Samantha J SJ Kennedy Ciara A CA Watt Stephen S Bähler Jürg J Whitehall Simon K SK

Eukaryotic cell 20080118 3

A component of the cellular response to zinc deficiency operates via control of transcript abundance. Therefore, microarray analysis was employed to identify Schizosaccharomyces pombe genes whose mRNA levels are regulated by intracellular zinc status. A set of 57 genes whose mRNA levels were substantially reduced in response to zinc deficiency was identified, while the mRNA levels of 63 genes were increased by this condition. In order to investigate the mechanisms that control these responses, a ...[more]

PMID: 18203864

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