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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Xenopus embryos in which fibroblast growth factor (FGF) signalling was inhibited by two different dominant negative FGF receptors

ABSTRACT: Genes regulated by the fibroblast growth factor (FGF) signalling pathway were indentified in the early development of the amphibian Xenopus laevis by comparing gene expression in control embryos and embryos in which FGF signalling was inhibited by two different dominant negative FGF receptors.

ORGANISM(S): Xenopus laevis

SUBMITTER: Naveed Aziz

PROVIDER: E-MEXP-2058 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Characterisation of the fibroblast growth factor dependent transcriptome in early development.

Branney Peter A PA Faas Laura L Steane Sarah E SE Pownall Mary Elizabeth ME Isaacs Harry V HV

PloS one 20090331 3

<h4>Background</h4>FGF signaling has multiple roles in regulating processes in animal development, including the specification and patterning of the mesoderm. In addition, FGF signaling supports self renewal of human embryonic stem cells and is required for differentiation of murine embryonic stem cells into a number of lineages.<h4>Methodology/principal findings</h4>Given the importance of FGF signaling in regulating development and stem cell behaviour, we aimed to identify the transcriptional ...[more]

PMID: 19333377

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