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The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate

ABSTRACT: Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with components of the Nuclear Receptor Corepressor Complex 1 and 2 (NCoR1 and NCoR2). Upon attenuation of Fgf signalling, unphosphorylated, nuclear Erf recruits the NCoR1/2 complex to key trophoblast genes, brings about their transcriptional silencing and facilitates differentiation and placental development.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Trophoblast Stem Cell

SUBMITTER: Richard Imre

LAB HEAD: Paulina A. Latos

PROVIDER: PXD037892 | Pride | 2023-04-26

REPOSITORIES: Pride

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			Action	DRS
	20170104_QexHF3_RSLC6_Latos_Mendjan_IMBA_shotgun_TMT_Frak35_1h_20perc.raw	Raw
	20170104_QexHF3_RSLC6_Latos_Mendjan_IMBA_shotgun_TMT_Frak36_1h_20perc.raw	Raw
	20170104_QexHF3_RSLC6_Latos_Mendjan_IMBA_shotgun_TMT_Frak37_1h_20perc.raw	Raw
	20170104_QexHF3_RSLC6_Latos_Mendjan_IMBA_shotgun_TMT_Frak38_1h_20perc.raw	Raw
	20170104_QexHF3_RSLC6_Latos_Mendjan_IMBA_shotgun_TMT_Frak39_1h_20perc.raw	Raw

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The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate

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