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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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KLF10 targets

ABSTRACT: Experiment comparing the liver transcriptome from wild type and KLF10 deficient mice

ORGANISM(S): Mus musculus

SUBMITTER: Franck Delaunay

PROVIDER: E-MEXP-2089 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver.

Guillaumond Fabienne F Gréchez-Cassiau Aline A Subramaniam Malayannan M Brangolo Sophie S Peteri-Brünback Brigitta B Staels Bart B Fiévet Catherine C Spelsberg Thomas C TC Delaunay Franck F Teboul Michèle M

Molecular and cellular biology 20100412 12

The circadian timing system coordinates many aspects of mammalian physiology and behavior in synchrony with the external light/dark cycle. These rhythms are driven by endogenous molecular clocks present in most body cells. Many clock outputs are transcriptional regulators, suggesting that clock genes primarily control physiology through indirect pathways. Here, we show that Krüppel-like factor 10 (KLF10) displays a robust circadian expression pattern in wild-type mouse liver but not in clock-def ...[more]

PMID: 20385766

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