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Transcription profiling of mouse embryonic stem cells to determine the effect of phosphorylation of TIF1beta on cell differentiation

ABSTRACT: The effect for cell differentiation of phosphorylation of TIF1beta (S824) on the regulation of pluripotency in mouse ES cells was then evaluated. Single amino acid mutagenesis was performed from serine 824 to aspartic acid (SD) or alanine (SA) to mimic phosphorylated or non-phosphorylated versions of TIF1beta, respectively.

ORGANISM(S): Mus musculus

SUBMITTER: Yasuhiro Seki 

PROVIDER: E-MEXP-2121 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner.

Seki Yasuhiro Y   Kurisaki Akira A   Watanabe-Susaki Kanako K   Nakajima Yoshiro Y   Nakanishi Mio M   Arai Yoshikazu Y   Shiota Kunio K   Sugino Hiromu H   Asashima Makoto M  

Proceedings of the National Academy of Sciences of the United States of America 20100527 24

Transcription networks composed of various transcriptional factors specifically expressed in undifferentiated embryonic stem (ES) cells have been implicated in the regulation of pluripotency in ES cells. However, the molecular mechanisms responsible for self-renewal, maintenance of pluripotency, and lineage specification during differentiation of ES cells are still unclear. The results of this study demonstrate that a phosphorylation-dependent chromatin relaxation factor, transcriptional interme  ...[more]

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