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MicroRNA profiling of mouse embryo gonad during the critical period of sex determination

ABSTRACT: Expression profiling of micro RNAs in mouse embryonic gonads before (11.5 days post coitum) and after (13.5 days post coitum) the critical period of sex determination

ORGANISM(S): Mus musculus

SUBMITTER: Miguel Burgos

PROVIDER: E-MEXP-2252 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells.

Real Francisca M FM Sekido Ryohei R Lupiáñez Darío G DG Lovell-Badge Robin R Jiménez Rafael R Burgos Miguel M

Biology of reproduction 20131004 4

In mammals, sex differentiation depends on gonad development, which is controlled by two groups of sex-determining genes that promote one gonadal sex and antagonize the opposite one. SOX9 plays a key role during testis development in all studied vertebrates, whereas it is kept inactive in the XX gonad at the critical time of sex determination, otherwise, ovary-to-testis gonadal sex reversal occurs. However, molecular mechanisms underlying repression of Sox9 at the beginning of ovarian developmen ...[more]

PMID: 23946534

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