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Transcription profiling of Danio rerio livers following chronic waterborne copper exposure

ABSTRACT: Zebrafish exposed to 2 waterborne copper concentrations (8 & 15 ug/L) in softwater for 21 days. Fish were terminally sampled and livers extracted for RNA extraction and hybridization to micorarrays

ORGANISM(S): Danio rerio

SUBMITTER: Paul Craig

PROVIDER: E-MEXP-2287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio.

Craig Paul M PM Hogstrand Christer C Wood Chris M CM McClelland Grant B GB

Physiological genomics 20090929 1

Although copper (Cu) is an essential micronutrient for all organisms, in excess, waterborne Cu poses a significant threat to fish from the cellular to population level. We examined the physiological and gene expression endpoints that chronic waterborne Cu exposure (21 d) imposes on soft-water acclimated zebrafish at two environmentally relevant concentrations: 8 microg/l (moderate) and 15 microg/l (high). Using a 16,730 65-mer oligonucleotide customized zebrafish microarray chip related to metal ...[more]

PMID: 19789285

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