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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human U937 acute myelogenous leukemia cells treated with the antihelmintic flubendazole

ABSTRACT: Gene expression profiling of U937 cells treated with or without flubendazole (1 microM, 4 hr incubation)

ORGANISM(S): Homo sapiens

SUBMITTER: Mahadeo Sukhai

PROVIDER: E-MEXP-2352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.

Spagnuolo Paul A PA Hu Jiayi J Hurren Rose R Wang Xiaoming X Gronda Marcela M Sukhai Mahadeo A MA Di Meo Ashley A Boss Jonathan J Ashali Iman I Beheshti Zavareh Reza R Fine Noah N Simpson Craig D CD Sharmeen Sumaiya S Rottapel Rob R Schimmer Aaron D AD

Blood 20100326 23

On-patent and off-patent drugs with previously unrecognized anticancer activity could be rapidly repurposed for this new indication given their prior toxicity testing. To identify such compounds, we conducted chemical screens and identified the antihelmintic flubendazole. Flubendazole induced cell death in leukemia and myeloma cell lines and primary patient samples at nanomolar concentrations. Moreover, it delayed tumor growth in leukemia and myeloma xenografts without evidence of toxicity. Mech ...[more]

PMID: 20348394

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