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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human embryonic stem cells in response to valproic acid and valproic acid analogs

ABSTRACT: Transcriptional profiling of valproic acid and valproic acid analogs in human embryonic stem cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Mans Jergil

PROVIDER: E-MEXP-2374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcription profiling of Mus Musculus embryonic stem cell line R1 exposures to Valproic acid and VPA analogs to investigate VPA as a potent inducer of neural tube defects

Project description:Valproic acid (VPA) is a potent inducer of neural tube defects (ntd:s) in both human and mouse, but its mechanism of teratogenicity is not know. The mouse embryonic stem cell line R1, may be relevant as an in vitro model of teratogenicity and was evaluated with exposures to VPA,and the two VPA anlogs (S)-2-pentyl-4-pentynoic acid, and 2-ethyl-4-methyl-pentanoic acid to profile the gene expression response. Those profiles may reveal biomarkers of teratogenic exposures in an in vitro system as well as give mechanistic input of the teratogenicity of VPA.

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Transcription profiling of mouse pluripotent embryocarcinoma cell line P19 after sodium valproate treatment to investigate its mechanism of teratogenicity

Project description:In the process of evaluating teratogenic properties of xenobiotica, the consumption of laboratory animals is high and costly which makes the development of alternative methods desirable. The pluripotent embryocarcinoma cell line P19, which closely resembles the early stage of an embryo, may be relevant as an in vitro model of teratogenicity. The antiepileptic drug Valproic acid (VPA) is a potent inducer of neural tube defects (ntd:s) in both human and mouse, but its mechanism of teratogenicity is not know. P19 cells were here treated with sodium valproate in a both time and dose dependent matter to profile the gene expression response with Codelink UniSet Mouse 20K I Bioarrays. This profile may reveal biomarkers of ntd:s as well as give mechanistic input of the teratogenicity of VPA.

2008-01-23 | E-MEXP-981 | biostudies-arrayexpress

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Project description:Parallel transcription profiling of cardiomyocyte clusters derived from human embryonic stem cells. Both mRNA (E-MEXP-2654) and miRNA (this experiment) transcription are measured and fetal and adult heart tissues are included as controls. This experiment was updated on 7th July 2011 to fix incorrect AH6 and FH3 files

2011-03-30 | E-MEXP-2655 | biostudies-arrayexpress

Expression of microRNAs and their target mRNAs in hESC-derived cardiomyocyte clusters and in heart tissue_mRNA_data

Project description:Parallel transcription profiling of cardiomyocyte clusters derived from human embryonic stem cells. Both mRNA (this experiment) and miRNA (see E-MEXP-2655) transcription are measured and fetal and adult heart tissues are included as controls. This experiment was updated on 7th July 2011 to fix incorrect AH6 and FH3 files.

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Project description:Ex vivo monocytes of HIV patients in different stages of the disease were compared with monocytes from healthy control donors.

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Transcription profiling of mouse after gonadectomy and treatment with estradiol, dihydrotestosterone or vehicle to compare gene expression in gastrocnemius

Project description:Treatment of gonadectomized mice with estradiol, dihydrotestosterone or vehicle to compare gene expression in gastrocnemius.

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Transcription profiling of human CD133 and CD34 positive hematopoietic stem cells imuno-magnetically isolated from bone marrow and umbilical cord blood

Project description:Expression Profiling of CD133 and CD34 positive Hematopoietic Stem Cells imuno-magnetically isolated from Bone Marrow and Umbilical Cord Blood

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Interactome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks.

Project description:Possible interactions between endometrium and implanting embryo in humans

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Transcription profiling of human thyroid papillary carcinoma cells treated with TGF-b or untreated

Project description:We used primary culture of Human thyroid papillary carcinoma to perform the experiment. We make two group one without TGF-b treatment and another with 2nanogr of TGF-b for 4 days. The RNA was extracted and the samples were processed for the array assay.<br><br><br><br>

2009-11-23 | E-MEXP-2045 | biostudies-arrayexpress

Transcription profiling time series of human endothelial cells invading into a three-dimensional collagen matrix

Project description:Gene expression profiling studies were performed at various times using a defined in vitro endothelial cell invasion assay system. Total RNA from invading cells was isolated at 0, 6, 12 and 18 hours and subjected to microarray analyses.

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