Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of homo sapiens (human) SKBR-3 cells treated with 0.1 uM RA vs controls


ABSTRACT: SKBR-3 cells were treated with control or 0.1uM RA for 48 hours

ORGANISM(S): Homo sapiens

SUBMITTER: Priya Prahalad 

PROVIDER: E-MEXP-2417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Retinoic acid mediates regulation of network formation by COUP-TFII and VE-cadherin expression by TGFbeta receptor kinase in breast cancer cells.

Prahalad Priya P   Dakshanamurthy Sivanesan S   Ressom Habtom H   Byers Stephen W SW  

PloS one 20100406 4


Tumor development, growth, and metastasis depend on the provision of an adequate vascular supply. This can be due to regulated angiogenesis, recruitment of circulating endothelial progenitors, and/or vascular transdifferentiation. Our previous studies showed that retinoic acid (RA) treatment converts a subset of breast cancer cells into cells with significant endothelial genotypic and phenotypic elements including marked induction of VE-cadherin, which was responsible for some but not all morpho  ...[more]

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