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Transcription profiling of human intestinal versus dermal lymphatic endothelial cells

ABSTRACT: In this analysis we have compared the gene expression profiles of lymphatic endothelial cells (LECs) isolated from human intestine (iLECs) versus LECs from human skin (dLECs).

ORGANISM(S): Homo sapiens

SUBMITTER: Camilla Norrmen

PROVIDER: E-MEXP-2452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.

Norrmén Camilla C Vandevelde Wouter W Ny Annelii A Saharinen Pipsa P Gentile Massimiliano M Haraldsen Guttorm G Puolakkainen Pauli P Lukanidin Eugene E Dewerchin Mieke M Alitalo Kari K Petrova Tatiana V TV

Blood 20091130 4

The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human der ...[more]

PMID: 19965622

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