Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human blood and lymphatic endothelial cells (BECs and LECs) with and without culture in order to evaluate the artefact of cell culture on the level of the transcriptome


ABSTRACT: We compared human blood and lymphatic endothelial cells (BECs and LECs) with and without culture in order to evaluate the artefact of cell culture on the level of the transcriptome.

ORGANISM(S): Homo sapiens

SUBMITTER: Ingrid Raab 

PROVIDER: E-MEXP-455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The in vivo functions of lymphatic endothelial cells depend on their microenvironment, which cannot be fully reproduced in vitro. Because of technical limitations, gene expression in uncultured, "ex vivo" lymphatic endothelial cells has not been characterized at the molecular level. We combined tissue micropreparation and direct cell isolation with DNA chip experiments to identify 159 genes differentiating human lymphatic endothelial cells from blood vascular endothelial cells ex vivo. The same  ...[more]

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