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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profiling of Drosophila melanogaster cell lines S2 and Kc with Nup153 RNAi-mediated depletion.

ABSTRACT: Expression profiling of Nup153 RNAi-mediated depletion in Drosophila S2 and Kc cells. This experiment is related to experiment E-MEXP-2525.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Juan Vaquerizas

PROVIDER: E-MEXP-2523 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome.

Vaquerizas Juan M JM Suyama Ritsuko R Kind Jop J Miura Kota K Luscombe Nicholas M NM Akhtar Asifa A

PLoS genetics 20100212 2

Transcriptional regulation is one of the most important processes for modulating gene expression. Though much of this control is attributed to transcription factors, histones, and associated enzymes, it is increasingly apparent that the spatial organization of chromosomes within the nucleus has a profound effect on transcriptional activity. Studies in yeast indicate that the nuclear pore complex might promote transcription by recruiting chromatin to the nuclear periphery. In higher eukaryotes, h ...[more]

PMID: 20174442

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