Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of mouse B cells from wild type or mir-155 deficient mice, treated with a-mir155 PNA

ABSTRACT: B cells were extracted from spleens of mice treated with PNA a-miR155 and vehicle treated mice either wild type or mir-155 deficient. All mice received LPS to induce mir155 expression.

ORGANISM(S): Mus musculus

SUBMITTER: Elena Vigorito

PROVIDER: E-MEXP-2587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.

Fabani Martin M MM Abreu-Goodger Cei C Williams Donna D Lyons Paul A PA Torres Adrian G AG Smith Kenneth G C KG Enright Anton J AJ Gait Michael J MJ Vigorito Elena E

Nucleic acids research 20100311 13

MicroRNAs (miRNAs) play an important role in diverse physiological processes and are potential therapeutic agents. Synthetic oligonucleotides (ONs) of different chemistries have proven successful for blocking miRNA expression. However, their specificity and efficiency have not been fully evaluated. Here, we show that peptide nucleic acids (PNAs) efficiently block a key inducible miRNA expressed in the haematopoietic system, miR-155, in cultured B cells as well as in mice. Remarkably, miR-155 inh ...[more]

PMID: 20223773

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Dataset Information

Transcription profiling of mouse B cells from wild type or mir-155 deficient mice, treated with a-mir155 PNA

Publications

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.

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