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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human HT29 colorectal cells treated with eicosapentaenoic acid

ABSTRACT: Effects of eicosapentaenoic acid on gene expression profiles in HT29 human colorectal cells

ORGANISM(S): Homo sapiens

SUBMITTER: Ruan Elliott

PROVIDER: E-MEXP-2673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of the Eph receptor pathway as a novel target for eicosapentaenoic acid (EPA) modification of gene expression in human colon adenocarcinoma cells (HT-29).

Doleman Joanne F JF Eady John J JJ Elliott Ruan M RM Foxall Rob J RJ Seers John J Johnson Ian T IT Lund Elizabeth K EK

Nutrition & metabolism 20100712

<h4>Background</h4>The health benefits of polyunsaturated fatty acids (PUFAs), particularly those of the n-3 series are well documented. The mechanisms by which these effects are mediated are not fully clarified.<h4>Methods</h4>We used microarrays to assess the effects on gene expression in HT29 colon adenocarcinoma cells of exposure to the n-3 fatty acid eicosapentaenoic acid (EPA). HT29 cells were cultured with EPA (150 muM) for up to 24 hr prior to harvesting and isolation of RNA. Microarray ...[more]

PMID: 20624275

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