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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human cell lines expressing high levels of tamoxifen-induced DDIT3

ABSTRACT: Identification of genes and functions regulated by DDIT3/GADD153/CHOP by transcriptional profiling of cell lines expressing high levels of tamoxifen induced DDIT3.

ORGANISM(S): Homo sapiens

SUBMITTER: Alexandra Jauhiainen

PROVIDER: E-MEXP-2709 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153.

Jauhiainen Alexandra A Thomsen Christer C Strömbom Linda L Grundevik Pernilla P Andersson Carola C Danielsson Anna A Andersson Mattias K MK Nerman Olle O Rörkvist Linda L Ståhlberg Anders A Åman Pierre P

PloS one 20120409 4

DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress response, but its target genes and functions are not well characterized. Here, we applied a genome wide microarray based expression analysis to identify DDIT3 target genes and functions. By analyzing cells carrying tamoxifen inducible DDIT3 expression constructs we show distinct gene expression profiles for cells with cy ...[more]

PMID: 22496745

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