Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
DISEASE(S): pneumococcal meningitis
SUBMITTER: Cornelia Blaser
PROVIDER: E-MEXP-2953 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20110311 3
Streptococcus pneumoniae is the most common pathogen causing non-epidemic bacterial meningitis worldwide. The immune response and inflammatory processes contribute to the pathophysiology. Hence, the anti-inflammatory dexamethasone is advocated as adjuvant treatment although its clinical efficacy remains a question at issue. In experimental models of pneumococcal meningitis, dexamethasone increased neuronal damage in the dentate gyrus. Here, we investigated expressional changes in the hippocampus ...[more]