Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of rat cerebral cortex and hippocampus from animals with pneumococcal meningitis treated with dexamethasone


ABSTRACT: Effect of adjuvant dexamethasone treatment on gene expression in the hippocampus and cortex of control rats or rats suffering from pneumococcal meningitis which were sacrificed 72 h after infection.

ORGANISM(S): Rattus norvegicus

DISEASE(S): pneumococcal meningitis

SUBMITTER: Cornelia Blaser 

PROVIDER: E-MEXP-2953 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Adjunctive dexamethasone affects the expression of genes related to inflammation, neurogenesis and apoptosis in infant rat pneumococcal meningitis.

Blaser Cornelia C   Wittwer Matthias M   Grandgirard Denis D   Leib Stephen L SL  

PloS one 20110311 3


Streptococcus pneumoniae is the most common pathogen causing non-epidemic bacterial meningitis worldwide. The immune response and inflammatory processes contribute to the pathophysiology. Hence, the anti-inflammatory dexamethasone is advocated as adjuvant treatment although its clinical efficacy remains a question at issue. In experimental models of pneumococcal meningitis, dexamethasone increased neuronal damage in the dentate gyrus. Here, we investigated expressional changes in the hippocampus  ...[more]

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