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Transcription profiling by array of rat cerebral cortex and hippocampus from animals with pneumococcal meningitis treated with dexamethasone

ABSTRACT: Effect of adjuvant dexamethasone treatment on gene expression in the hippocampus and cortex of control rats or rats suffering from pneumococcal meningitis which were sacrificed 72 h after infection.

ORGANISM(S): Rattus norvegicus

DISEASE(S): pneumococcal meningitis

SUBMITTER: Cornelia Blaser

PROVIDER: E-MEXP-2953 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Adjunctive dexamethasone affects the expression of genes related to inflammation, neurogenesis and apoptosis in infant rat pneumococcal meningitis.

Blaser Cornelia C Wittwer Matthias M Grandgirard Denis D Leib Stephen L SL

PloS one 20110311 3

Streptococcus pneumoniae is the most common pathogen causing non-epidemic bacterial meningitis worldwide. The immune response and inflammatory processes contribute to the pathophysiology. Hence, the anti-inflammatory dexamethasone is advocated as adjuvant treatment although its clinical efficacy remains a question at issue. In experimental models of pneumococcal meningitis, dexamethasone increased neuronal damage in the dentate gyrus. Here, we investigated expressional changes in the hippocampus ...[more]

PMID: 21412436

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