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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis

ABSTRACT: Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcriptomics and measurement of cellular nicotine amide adenine dinucleotide content. The data provides evidence that vitamin B6 is neuroprotecitve in terms of reduced hippocampal apoptosis involving reduction of the inflammatory response, preservation of cellular energy stores and up-regulated brain-derived neurotrophic factor levels.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Denise Burri

PROVIDER: E-MEXP-3555 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis.

Zysset-Burri Denise C DC Bellac Caroline L CL Leib Stephen L SL Wittwer Matthias M

BMC infectious diseases 20130827

<h4>Background</h4>Bacterial meningitis caused by Streptococcus pneumoniae leads to death in up to 30% of patients and leaves up to half of the survivors with neurological sequelae. The inflammatory host reaction initiates the induction of the kynurenine pathway and contributes to hippocampal apoptosis, a form of brain damage that is associated with learning and memory deficits in experimental paradigms. Vitamin B6 is an enzymatic cofactor in the kynurenine pathway and may thus limit the accumul ...[more]

PMID: 23977941

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