Unknown,Transcriptomics,Genomics,Proteomics

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Bordetella bronchiseptica RB50 iron limitation 2


ABSTRACT: Bordetella bronchiseptica RB50 was shifted from iron replete to either iron depleted or iron replete media, and samples were taken post shift for transcriptional profiling

ORGANISM(S): Bordetella bronchiseptica

SUBMITTER: Craig Cummings 

PROVIDER: E-MEXP-3076 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression.

Brickman Timothy J TJ   Cummings Craig A CA   Liew Sin-Yee SY   Relman David A DA   Armstrong Sandra K SK  

Journal of bacteriology 20110708 18


Serological studies of patients with pertussis and the identification of antigenic Bordetella pertussis proteins support the hypothesis that B. pertussis perceives an iron starvation cue and expresses multiple iron source utilization systems in its natural human host environment. Furthermore, previous studies using a murine respiratory tract infection model showed that several of these B. pertussis iron systems are required for colonization and persistence and are differentially expressed over t  ...[more]

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