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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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KFAM CGH

ABSTRACT: Breast cancer samples from patients with BRCA2 mutation. Comparative genomic hybridization by array of BRCA2 tumors.

ORGANISM(S): Homo sapiens

SUBMITTER: Audrey Rouault

PROVIDER: E-MEXP-3690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations.

Rouault Audrey A Banneau Guillaume G Macgrogan Gaëtan G Jones Natalie N Elarouci Nabila N Barouk-Simonet Emmanuelle E Venat Laurence L Coupier Isabelle I Letouzé Eric E de Reyniès Aurélien A Bonnet Françoise F Iggo Richard R Sévenet Nicolas N Longy Michel M

PloS one 20121221 12

<h4>Introduction</h4>Germline BRCA1 or BRCA2 mutations account for 20-30% of familial clustering of breast cancer. The main indication for BRCA2 screening is currently the family history but the yield of mutations identified in patients selected this way is low.<h4>Methods</h4>To develop more efficient approaches to screening we have compared the gene expression and genomic profiles of BRCA2-mutant breast tumors with those of breast tumors lacking BRCA1 or BRCA2 mutations.<h4>Results</h4>We iden ...[more]

PMID: 23284877

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