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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Bordetella pertussis Tohama I iron limitation 1

ABSTRACT: B. pertussis Tohama I was grown in iron-depleted or iron-replete media and sampled at several time points to assess global gene expression

ORGANISM(S): Bordetella pertussis

SUBMITTER: Craig Cummings

PROVIDER: E-MEXP-3263 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression.

Brickman Timothy J TJ Cummings Craig A CA Liew Sin-Yee SY Relman David A DA Armstrong Sandra K SK

Journal of bacteriology 20110708 18

Serological studies of patients with pertussis and the identification of antigenic Bordetella pertussis proteins support the hypothesis that B. pertussis perceives an iron starvation cue and expresses multiple iron source utilization systems in its natural human host environment. Furthermore, previous studies using a murine respiratory tract infection model showed that several of these B. pertussis iron systems are required for colonization and persistence and are differentially expressed over t ...[more]

PMID: 21742863

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