Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression in adipose tissues of polygenic Fat mice


ABSTRACT: Gene expression in adipose and other tissues of polygenic Fat and Lean mice.

ORGANISM(S): Mus musculus

SUBMITTER: Donald Dunbar 

PROVIDER: E-MEXP-3091 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.

Morton Nicholas M NM   Nelson Yvonne B YB   Michailidou Zoi Z   Di Rollo Emma M EM   Ramage Lynne L   Hadoke Patrick W F PW   Seckl Jonathan R JR   Bunger Lutz L   Horvat Simon S   Kenyon Christopher J CJ   Dunbar Donald R DR  

PloS one 20110907 9


<h4>Background</h4>Obesity and metabolic syndrome results from a complex interaction between genetic and environmental factors. In addition to brain-regulated processes, recent genome wide association studies have indicated that genes highly expressed in adipose tissue affect the distribution and function of fat and thus contribute to obesity. Using a stratified transcriptome gene enrichment approach we attempted to identify adipose tissue-specific obesity genes in the unique polygenic Fat (F) m  ...[more]

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