Mouse liver macrophage gene expression following hepatic fibrosis
Ontology highlight
ABSTRACT:
Macrophages were isolated from mouse livers 24 hours (inflammation) and 72 hours (resolution) following injury (hepatic fibrosis).
RNAs were prepared and hybrised on Affymetrix Mouse Genome 1.0 ST arrays.
ORGANISM(S): Mus musculus
SUBMITTER: Donald Dunbar
PROVIDER: E-MEXP-3177 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Ramachandran Prakash P Pellicoro Antonella A Vernon Madeleine A MA Boulter Luke L Aucott Rebecca L RL Ali Aysha A Hartland Stephen N SN Snowdon Victoria K VK Cappon Andrea A Gordon-Walker Timothy T TT Williams Mike J MJ Dunbar Donald R DR Manning Jonathan R JR van Rooijen Nico N Fallowfield Jonathan A JA Forbes Stuart J SJ Iredale John P JP
Proceedings of the National Academy of Sciences of the United States of America 20121024 46
Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl(4)-induced model of reversible hepatic fibrosis to identify and characterize the macrophage phenotype responsible for tissue remodeling: the hitherto elusive restorative macrophage. This CD11B(hi) F4/80(int) Ly-6C(lo) macrophage subset was most abundant in livers during maximal fibrosis resolution and represented the principle matrix metalloproteinase (MMP) -expressing subse ...[more]
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This is a sub-model of a three-step
inflammatory response modelling study. The model includes distinct
populations of white blood cells namely, macrophages and active and
apoptotic neutrophil populations. Neutrophil apoptosis rate is
predicted to be crucial for the qualitative nature of the
system.
This model is described in the article:
The resolution of
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Dunster JL, Byrne HM, King JR.
Bull. Math. Biol. 2014 Aug; 76(8):
1953-1980
Abstract:
There is growing interest in inflammation due to its
involvement in many diverse medical conditions, including
Alzheimer's disease, cancer, arthritis and asthma. The
traditional view that resolution of inflammation is a passive
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that can be manipulated therapeutically. This shift in mindset
has stimulated a resurgence of interest in the biological
mechanisms by which inflammation resolves. The
anti-inflammatory processes central to the resolution of
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