Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of rat kidney tubules infected with uropathogenic E. coli to study early local bacterial inflammation

ABSTRACT: The transcriptome of early local kidney inflammation was profiled. Rat kidney tubules were injected with uropathogenic E. coli or PBS control. After incubation time, kidney samples were processed and transcription was assayed. Three rats were used per condition.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jorrit Boekel

PROVIDER: E-MEXP-2136 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparative tissue transcriptomics reveal prompt inter-organ communication in response to local bacterial kidney infection.

Boekel Jorrit J Källskog Orjan O Rydén-Aulin Monica M Rhen Mikael M Richter-Dahlfors Agneta A

BMC genomics 20110221

<h4>Background</h4>Mucosal infections elicit inflammatory responses via regulated signaling pathways. Infection outcome depends strongly on early events occurring immediately when bacteria start interacting with cells in the mucosal membrane. Hitherto reported transcription profiles on host-pathogen interactions are strongly biased towards in vitro studies. To detail the local in vivo genetic response to infection, we here profiled host gene expression in a recent experimental model that assures ...[more]

PMID: 21338499

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Dataset Information

Transcription profiling of rat kidney tubules infected with uropathogenic E. coli to study early local bacterial inflammation

Publications

Comparative tissue transcriptomics reveal prompt inter-organ communication in response to local bacterial kidney infection.

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