Ontology highlight
ABSTRACT:
ORGANISM(S): Plasmodium falciparum
SUBMITTER: Emmanuel BISCHOFF
PROVIDER: E-MEXP-319 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ralph Stuart A SA Bischoff Emmanuel E Mattei Denise D Sismeiro Odile O Dillies Marie-Agnès MA Guigon Ghislaine G Coppee Jean-Yves JY David Peter H PH Scherf Artur A
Genome biology 20051031 11
<h4>Background</h4>Plasmodium falciparum, the causative agent of the most severe form of malaria, undergoes antigenic variation through successive presentation of a family of antigens on the surface of parasitized erythrocytes. These antigens, known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, are subject to a mutually exclusive expression system, and are encoded by the multigene var family. The mechanism whereby inactive var genes are silenced is poorly understood. ...[more]