Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional Profiles of peripheral blood mononuclear cells - PBMC - from Type 2 diabetes mellitus Patients

ABSTRACT: The oligo microarrays were used to determine gene expression profiles of PBMC from type 2 diabetes mellitus (T2DM) patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Geraldo Passos 

PROVIDER: E-MEXP-3287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation.

Evangelista Adriane F AF   Collares Cristhianna V A CV   Xavier Danilo J DJ   Macedo Claudia C   Manoel-Caetano Fernanda S FS   Rassi Diane M DM   Foss-Freitas Maria C MC   Foss Milton C MC   Sakamoto-Hojo Elza T ET   Nguyen Catherine C   Puthier Denis D   Passos Geraldo A GA   Donadi Eduardo A EA  

BMC medical genomics 20140523

<h4>Background</h4>Type 1 diabetes (T1D) is an autoimmune disease, while type 2 (T2D) and gestational diabetes (GDM) are considered metabolic disturbances. In a previous study evaluating the transcript profiling of peripheral mononuclear blood cells obtained from T1D, T2D and GDM patients we showed that the gene profile of T1D patients was closer to GDM than to T2D. To understand the influence of demographical, clinical, laboratory, pathogenetic and treatment features on the diabetes transcript  ...[more]

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