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MicroRNA expression profile of medullary thymic epithelial cells - mTEC 3.10 strain - submitted of in vitro Aire knockdown - siRNA silencing-

ABSTRACT: The oligo microarrays were used to determine microRNA expression profiles of medullary thymic epithelial cells (mTECs) submitted of in vitro Aire Knockdown (siRNA silencing).

ORGANISM(S): Mus musculus

SUBMITTER: Geraldo Passos

PROVIDER: E-MEXP-3359 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells.

Macedo Claudia C Evangelista Adriane F AF Marques Márcia M MM Octacílio-Silva Shirlei S Donadi Eduardo A EA Sakamoto-Hojo Elza T ET Passos Geraldo A GA

Immunobiology 20120702 4

The autoimmune regulator (Aire) is a transcription factor that controls the ectopic expression of a large set of peripheral tissue antigen (PTA) genes in medullary thymic epithelial cells (mTECs). Recent evidence has demonstrated that Aire releases stalled RNA polymerase II (RNA Pol II) from blockage at the promoter region of its target genes. Given that, in addition to messenger RNAs (mRNA), RNA Pol II also transcribes microRNAs (miRNAs), we raised the hypothesis that Aire might play a role as ...[more]

PMID: 22883565

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