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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of adenoma and corresponding normal mucosa in human colorectal cancer cases

ABSTRACT: The differences in gene expression profile between adenoma and corresponding normal mucosa in colorectal cancer cases.

ORGANISM(S): Homo sapiens

SUBMITTER: Sima Salahshor

PROVIDER: E-MEXP-341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis.

Salahshor Sima S Goncalves Jason J Chetty Runjan R Gallinger Steven S Woodgett James R JR

BMC cancer 20050627

<h4>Background</h4>APC (Adenomatous polyposis coli) plays an important role in the pathogenesis of both familial and sporadic colorectal cancer. Patients carrying germline APC mutations develop multiple colonic adenomas at younger age and higher frequency than non-carrier cases which indicates that silencing of one APC allele may be sufficient to initiate the transformation process.<h4>Methods</h4>To elucidate the biological dysregulation underlying adenoma formation we examined global gene expr ...[more]

PMID: 15982419

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