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Transcription profiling of Salmonella enterica Typhimurium during infection of human epithelial cells

ABSTRACT: Epithelial cells are the first cell type Salmonella Typhimurium will encounter when infecting a host. Using DNA array techology we identified the Salmonella enterica Typhimurium genes regulated inside human epithelial cells and their variation through time.

ORGANISM(S): Salmonella typhimurium

SUBMITTER: Isabelle Hautefort

PROVIDER: E-MEXP-1368 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems.

Hautefort I I Thompson A A Eriksson-Ygberg S S Parker M L ML Lucchini S S Danino V V Bongaerts R J M RJ Ahmad N N Rhen M M Hinton J C D JC

Cellular microbiology 20071120 4

The biogenesis of the Salmonella-containing vacuole within mammalian cells has been intensively studied over recent years. However, the ability of Salmonella to sense and adapt to the intracellular environment of different types of host cells has received much less attention. To address this issue, we report the transcriptome of Salmonella enterica serovar Typhimurium SL1344 within epithelial cells and show comparisons with Salmonella gene expression inside macrophages. We report that S. Typhimu ...[more]

PMID: 18031307

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