Novel Small RNA Modulates Virulence in Francisella tularensis

ABSTRACT: Most sRNAs control the expression of target genes by interacting with their mRNA. The fvr1 (Francisella virulence RNA 1) gene is found in the IGR between FTL_0777 and FTL_0778 and its sequence does not overlap those of the flanking genes, indicating that its target(s) is located in trans. Base-pairing between a sRNA and target mRNA generally leads to changed translation and often the stability of the mRNA is affected as well. Therefore, to identify possible targets of Fvr1, we compared the transcriptomes of the LVS?fvr1(LVS, for Live Vaccine Strain) and LVS/pfvr1+ strains after growth in liquid broth.

ORGANISM(S): Francisella tularensis

SUBMITTER: Eric Frapy 

PROVIDER: E-MEXP-3424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress