Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Novel Small RNA Modulates Virulence in Francisella tularensis

ABSTRACT: Most sRNAs control the expression of target genes by interacting with their mRNA. The fvr1 (Francisella virulence RNA 1) gene is found in the IGR between FTL_0777 and FTL_0778 and its sequence does not overlap those of the flanking genes, indicating that its target(s) is located in trans. Base-pairing between a sRNA and target mRNA generally leads to changed translation and often the stability of the mRNA is affected as well. Therefore, to identify possible targets of Fvr1, we compared the transcriptomes of the LVS?fvr1(LVS, for Live Vaccine Strain) and LVS/pfvr1+ strains after growth in liquid broth.

ORGANISM(S): Francisella tularensis

SUBMITTER: Eric Frapy 

PROVIDER: E-MEXP-3424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of a novel small RNA modulating Francisella tularensis pathogenicity.

Postic Guillaume G   Dubail Iharilalao I   Frapy Eric E   Dupuis Marion M   Dieppedale Jennifer J   Charbit Alain A   Meibom Karin L KL  

PloS one 20120725 7

Francisella tularensis is a highly virulent bacterium responsible for the zoonotic disease tularemia. It is a facultative intracellular pathogen that replicates in the cytoplasm of host cells, particularly in macrophages. Here we show that F. tularensis live vaccine strain (LVS) expresses a novel small RNA (sRNA), which modulates the virulence capacities of the bacterium. When this sRNA, designated FtrC (for Francisella tularensis RNA C), is expressed at high levels, F. tularensis replicates in  ...[more]

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