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Transcription profiling of Francisella tularensis LVS wild type and hfq mutant strains grown on complex liquid medium

ABSTRACT: Comparison of Francisella tularensis LVS wild-type and hfq mutant strains grown in complex liquid broth.

ORGANISM(S): Francisella tularensis

SUBMITTER: Karin Meibom

PROVIDER: E-MEXP-1891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hfq, a novel pleiotropic regulator of virulence-associated genes in Francisella tularensis.

Meibom Karin L KL Forslund Anna-Lena AL Kuoppa Kerstin K Alkhuder Khaled K Dubail Iharilalao I Dupuis Marion M Forsberg Ake A Charbit Alain A

Infection and immunity 20090217 5

Francisella tularensis is a highly infectious pathogen that infects animals and humans, causing tularemia. The ability to replicate within macrophages is central for virulence and relies on expression of genes located in the Francisella pathogenicity island (FPI), as well as expression of other genes. Regulation of FPI-encoded virulence gene expression in F. tularensis involves at least four regulatory proteins and is not fully understood. Here we studied the RNA-binding protein Hfq in F. tulare ...[more]

PMID: 19223477

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