Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL

ABSTRACT: Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.

ORGANISM(S): Homo sapiens

DISEASE(S): no tendon xanthomas

SUBMITTER: Corina Junquera

PROVIDER: E-MEXP-360 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL.

Artieda Marta M Cenarro Ana A Junquera Corina C Lasierra Pilar P Martínez-Lorenzo María José MJ Pocoví Miguel M Civeira Fernando F

FEBS letters 20050801 20

Tendon xanthomas (TX) are pathognomonic lipid deposits commonly found in familial hypercholesterolemia (FH) patients. The aim of this study was to determine whether macrophages from FH patients with TX (TX+) have higher predisposition to foam cells formation after oxidized LDL (oxLDL) overload than those from FH patients without TX (TX-), and if their differential gene expression profile could explain these different phenotypes. Total RNA pools from macrophages from FH patients TX+ and TX- were ...[more]

PMID: 16083882

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Dataset Information

Transcription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL

Publications

Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL.

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