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Adhesion and bacteriocin production by Lactobacillus salivarius influence the intestinal epithelial cell transcriptional response

ABSTRACT: The effect of epithelial cell-bacterial interaction on gene transcription in the epithelial cells and bacterial cells in vitro. The transcriptional response elicited by the UCC118 sortase deletion mutant will be compared to that of the wild type UCC118.

ORGANISM(S): Homo sapiens

SUBMITTER: John O'Callaghan 

PROVIDER: E-MEXP-3616 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Influence of adhesion and bacteriocin production by Lactobacillus salivarius on the intestinal epithelial cell transcriptional response.

O'Callaghan John J   Buttó Ludovica F LF   MacSharry John J   Nally Kenneth K   O'Toole Paul W PW  

Applied and environmental microbiology 20120518 15

Lactobacillus salivarius strain UCC118 is a human intestinal isolate that has been extensively studied for its potential probiotic effects in human and animal models. The objective of this study was to determine the effect of L. salivarius UCC118 on gene expression responses in the Caco-2 cell line to improve understanding of how the strain might modulate intestinal epithelial cell phenotypes. Exposure of Caco-2 cells to UCC118 led to the induction of several human genes (TNFAIP3, NFKBIA, and BI  ...[more]

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