Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcriptional profile of pink1 mutant flies

ABSTRACT: Global analysis of transcriptional changes in Drosophila pink1 mutants.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: L. Miguel Martins 

PROVIDER: E-MEXP-3645 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.

Tufi Roberta R   Gandhi Sonia S   de Castro Inês P IP   Lehmann Susann S   Angelova Plamena R PR   Dinsdale David D   Deas Emma E   Plun-Favreau Hélène H   Nicotera Pierluigi P   Abramov Andrey Y AY   Willis Anne E AE   Mallucci Giovanna R GR   Loh Samantha H Y SH   Martins L Miguel LM  

Nature cell biology 20140119 2

Mutations in PINK1 cause early-onset Parkinson's disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1 as a central mechanism of PD pathogenesis. Here we show that global analysis of transcriptional changes in Drosophila pink1 mutants reveals an upregulation of genes involved in nucleotide metabolism, critical for neuronal mitochondrial DNA synthesis. These key transcriptional changes were also detected in brains of PD patients harbouring PI  ...[more]

Similar Datasets

Transcriptomics Transcription profiling by array of pink1 adult mutant flies with a 2-point time course
2020-07-20 | E-MTAB-6210 | biostudies-arrayexpress
Transcriptomics mRNA transcription profiling by array of adult flies expressing dPerk
2020-07-20 | E-MTAB-6097 | biostudies-arrayexpress
Transcriptomics Drosophila Johnston organ genes
2012-08-31 | E-MEXP-3609 | biostudies-arrayexpress
Transcriptomics Microarray Analysis of Starvation Responses in Drosophila Larvae
2012-03-21 | E-MEXP-3352 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Drosophila wild type and Ada2b knock out pupa
2009-04-25 | E-MEXP-2126 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Drosophila wild type and Ada2b knockout L3 larvae synchronized to spiracle eversion
2009-04-25 | E-MEXP-2125 | biostudies-arrayexpress
Transcriptomics Mushroom body cell type comparison
2013-01-10 | E-MEXP-3798 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Drosophila courtship-exposed male flies
2008-06-15 | E-GEOD-6655 | biostudies-arrayexpress
Transcriptomics mRNA transcription profiling by array of adult flies expressing a artificial construct designed to bring mitochondria and the endoplasmic reticulum in close proximity
2019-11-02 | E-MTAB-8468 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of intestinal tissue from Drosophila w1118 and p38c null mutation flies
2014-09-30 | E-MTAB-2740 | biostudies-arrayexpress